Defining brain mechanisms that control and adapt motivated behavior will not only advance addiction treatment. It will help society see that addiction is a disease that erodes free will, rather than representing a free will that asks for or deserves consequences of drug-use choices. This science has important implications for understanding addiction's comorbidity in mental illness and reducing associated public health and criminal justice burdens.

Cost conversations are essential to informed consent because patients have a right to information that they think is relevant, and patients overwhelmingly report that cost information is relevant to their medical decisions. Providers have an ethical responsibility to provide necessary information for informed consent, and therefore must discuss costs. The Shared Decision Making model is ideal for enabling this exchange of information, and decision aids are also helpful. Although barriers exist, many useful tools can help providers fulfill this obligation, and (...) encouraging progress is being made to improve cost transparency from insurers and facilities. (shrink)

Despite increasing scientific interest in self-generated thought-mental content largely independent of the immediate environment-there has yet to be any comprehensive synthesis of the subjective experience and neural correlates of affect in these forms of thinking. Here, we aim to develop an integrated affective neuroscience encompassing many forms of self-generated thought-normal and pathological, moderate and excessive, in waking and in sleep. In synthesizing existing literature on this topic, we reveal consistent findings pertaining to the prevalence, valence, and variability of emotion in (...) self-generated thought, and highlight how these factors might interact with self-generated thought to influence general well-being. We integrate these psychological findings with recent neuroimaging research, bringing attention to the neural correlates of affect in self-generated thought. We show that affect in self-generated thought is prevalent, positively biased, highly variable (both within and across individuals), and consistently recruits many brain areas implicated in emotional processing, including the orbitofrontal cortex, amygdala, insula, and medial prefrontal cortex. Many factors modulate these typical psychological and neural patterns, however; the emerging affective neuroscience of self-generated thought must endeavor to link brain function and subjective experience in both everyday self-generated thought as well as its dysfunctions in mental illness. (shrink)

In the maximal form of indirect development found in many taxa of marine invertebrates, embryonic cell lineages of fixed fate and limited division capacity give rise to the larval structures. The adult arises from set‐aside cells in the larva that are held out from the early embryonic specification processes, and that retain extensive proliferative capacity. We review the locations and fates of set‐aside cells in two protostomes, a lophophorate and a deuterostome. The distinct adult body plans of many phyla develop (...) from homologous set‐aside cells within homologous larvae. We argue that the stocks from which these phyla arose utilized these respective larvae, and the diversity of their adult body plans reflects diverse pattern formation processes executed in their set‐aside cell populations. Chordates and arthropods develop directly, but share adult characters with indirectly developing phyla. Thus the deuterostome and protostome stocks that were ancestral to chordates and arthropods, respectively, also utilized maximal indirect development. (shrink)

Núñez and colleagues (2019) question whether cognitive science still exists “as a coherent academic field with a well‐defined and cohesive interdisciplinary research program.” This worry may be premature on two grounds. First, we are not convinced that the Lakatosian criterion of coalescence around a core framework is the best standard for judging whether a field is well‐defined and productive. Second, although we acknowledge that cognitive science is not as visible as we would like, we doubt that this low profile accurately (...) reflects the state of actual research and teaching programs based on the cognitive science approach. (shrink)

Núñez and colleagues (2019) question whether cognitive science still exists “as a coherent academic field with a well‐defined and cohesive interdisciplinary research program.” This worry may be premature on two grounds. First, we are not convinced that the Lakatosian criterion of coalescence around a core framework is the best standard for judging whether a field is well‐defined and productive. Second, although we acknowledge that cognitive science is not as visible as we would like, we doubt that this low profile accurately (...) reflects the state of actual research and teaching programs based on the cognitive science approach. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

In this article, we develop and defend a new argument for animalism -- the thesis that we human persons are human animals. The argument takes this rough form: since our pets are animals, we are too. We’ll begin with remarks on animalism and its rivals, develop our main argument, and then defend it against a few replies.

It is widely suspected that arguments from conceivability, at least in some of their more notorious instances, are unsound. However, the reasons for the failure of conceivability arguments are less well agreed upon, and it remains unclear how to distinguish between sound and unsound instances of the form. In this paper I provide an analysis of the form of arguments from conceivability, and use this analysis to diagnose a systematic weakness in the argument form which reveals all its instances to (...) be, roughly, either uninformative or unsound. I illustrate this conclusion through a consideration of David Chalmers. (shrink)

One of the aspects of consciousness deserving of study is what might be called its subjective unity - the way in which, though conscious experience moves from object to object, and can be said to have distinct ‘states', it nevertheless in some sense apparently forms a singular flux divided only by periods of unconsciousness. The work of William James provides a valuable, and rather unique, source of analysis of this feature of consciousness; however, in my opinion, this component of James’ (...) theory of the mind has so far gone under-emphasized in the scholarly literature. This paper undertakes some philosophical geography, trying to draw out and elucidate some of the relevant ideas from James’ corpus, and also subjects those ideas to some analysis to try and assist in judgements of their current importance. (shrink)

Four experiments supported the hypothesis that ordinary people understand free will as meaning unconstrained choice, not having a soul. People consistently rated free will as being high unless reduced by internal constraints (i.e., things that impaired people’s mental abilities to make choices) or external constraints (i.e., situations that hampered people’s abilities to choose and act as they desired). Scientific paradigms that have been argued to disprove free will were seen as reducing, but usually not eliminating free will, and the reductions (...) were because of constrained conscious choice. We replicated findings that a minority of people think lacking a soul reduces free will. These reductions in perceived free will were fully explained by reductions in people’s perceived abilities to make conscious decisions. Thus, some people do think you need a soul to have free will—but it is because they think you need a soul to make conscious decisions. (shrink)

"In the United States, we try to comfort ourselves with the belief that this country, as the leading world power and industrial democracy, is different from the rest of the world--that we have solved our day-to-day problems. Such optimism--undergirded with the best of intentions--obscures the reality of the social problems that remain among us. To name only a few, these include violence, drugs, and other crime illiteracy, homelessness, and poverty and the rising rate of illegitimacy in our society. "A vigorous (...) debate over these issues, which are of such pressing concern, is taking place now in our country. It largely concerns the means we should use to address them: What is the proper role of the government in solving these problems without depriving individuals of their right to shape their own destinies?" --from the Introduction by Andrew R. Cecil. (shrink)

Are qualia natural kinds? In order to give this question slightly more focus, and to show why it might be an interesting question, let me begin by saying a little about what I take qualia to be, and what natural kinds. For the purposes of this paper, I shall be assuming a fairly full-blooded kind of phenomenal realism about qualia: qualia, thus, include the qualitative painfulness of pain (rather than merely the functional specification of pain states), the qualitative redness in (...) the visual field that typically accompanies red discriminations, the taste of lemon (independently of the fact that such states are normally caused by lemons and give rise to puckering of the lips, etc.), and so on. In other words, I am assuming the falsity of functionalism with respect to qualia, though I am not for a moment assuming dualism. (shrink)

Qualia have historically been thought to stand in a very different epistemological relation to the knower than does the external furniture of the world. The ‘raw feels’ of thought were often said to be ‘given’, while what we might call the content of that thought – for example, claims about the external world – was thought only more or less doubtfully true; and this was often said to be because we are ‘directly’ or ‘non-inferentially’ confronted by qualia or experiences, whereas (...) all other properties or objects are only mediately ‘connected’ to the perceiver. The modern turn in philosophy – spearheaded by Wittgen-stein, Sellars, Quine, Ryle and others – away from classical empiricism to today’s ‘post-postivistic’ philosophy, has apparently involved the rejection of this once familiar assumption. I argue a) that the rejection of a certain kind of epistemological foundationalism does not entail the rejection of phenomenal individuals tout court; and b) that qualia are in fact, in some epistemologically significant ways, given. (shrink)

"The French philosopher Nicolas Malebranche popularized the doctrine of occasionalism in the late seventeenth century. Occasionalism is the thesis that God alone is the true cause of everything that happens in the world, and created substances are merely "occasional causes." This doctrine was originally developed in medieval Islamic theology, and was widely rejected in the works of Christian authors in medieval Europe. Yet despite its heterodoxy, occasionalism was revived starting in the 1660s by French and Dutch followers of the philosophy (...) of René Descartes. Since the 1970s, there has been a growing body of literature on Malebranche and occasionalism. There has also been new work on the Cartesian occasionalists before Malebranche - including Arnold Geulincx, Geraud de Cordemoy and Louis de la Forge. But to date there has not been a systematic, book-length study of the reasoning that led Cartesian thinkers to adopt occasionalism, and the relationship of their arguments to Descartes' own views. This book expands on recent scholarship, to provide the first comprehensive account of seventeenth century occasionalism. Part I contrasts occasionalism with a theory of divine providence developed by Thomas Aquinas, in response to medieval occasionalists; it shows that Descartes' philosophy is compatible with Aquinas' theory, on which God "concurs" in all the actions of created beings. Part 2 reconstructs the arguments of Cartesians - such as Cordemoy and a Forge - who used Cartesian physics to argue for occasionalism. Finally, it shows how Malebranche's case for occasionalism combines philosophical theology with Cartesian metaphysics and mechanistic science"--. (shrink)

This paper deals with the relationship between the embodied cognition paradigm and two sets of its implications: its implications for the ontology of selves, and its implications for the nature and extent of phenomenal consciousness. There has been a recent wave of interest within cognitive science in the paradigm variously called ‘embodied,’ ‘extended,’ ‘situated’ or ‘distributed’ cognition. Although ideas applied in the embodied cognition research program can be traced back to the work of Heidegger, Piaget, Vygotsky, Merleau-Ponty, and Dewey, the (...) current thesis can be seen as a direct response and, in some cases, a proposed alternative to the cognitivist/classicist rule-based, information-processing model of cognition. Embodied cognition, by contrast, arises from real-time, goal-oriented bodily interactions with the world. I lay out three relations: the implications of embodiment for consciousness; the implications of embodiment for the self; and the tension between these two. I argue that the embodiment paradigm introduces a radical split between consciousness and the self, and that it does so by deflating our pre-theoretical instincts about consciousness and self in two different directions; however, I claim, what both these theoretical movements have in common is a scepticism about the notion of a psychological container defining a boundary between ‘inside’ and ‘outside.’ (203 words). (shrink)

The development of ethical guidelines and regulations regarding human subjects research has focused upon protection of vulnerable populations by relying on a limited typology of vulnerabilities. This results in several challenges: First, Institutional Review Boards struggle to interpret and apply the regulations because they are often vague and inconsistent. Second, applying the regulations to subjects who fit within multiple categories of vulnerability can lead to contradictions and the rejection of research that would be permissible if only one category were applicable. (...) Finally, some potential subjects have social and other context-based vulnerabilities that are not described in the federal regulations... (shrink)

Fully named _Discourse on the Method for Reasoning Well and for Seeking Truth in the Sciences_, this work offers the most complete presentation and defense of René Descartes’ method of intellectual inquiry— a method that greatly influenced both philosophical and scientific reasoning in the early modern world. Descartes’s timeless ideas strike an uncommon balance of novelty and familiarity, offering arguments concerning knowledge, science, and metaphysics that are as compelling in the 21st century as they were in the 17th. Ian Johnston’s (...) new translation of the original French text is modern, clear, and thoroughly annotated, ideal for readers unfamiliar with Descartes’ intellectual context. An approachable introduction engages both the historical and the philosophical aspects of the text, enabling the reader to interpret this easily misunderstood work within Descartes’ larger project. This edition joins Broadview’s growing list of affordable classic texts from the philosophical canon, adapted from Andrew Bailey’s popular anthology series _First Philosophy_. (shrink)

Considered a foundational text in modern philosophy, the _Meditations on First Philosophy_ presents numerous powerful arguments that to this day influence debates in epistemology, the philosophy of mind, and the philosophy of religion. This new translation incorporates revisions from the second Latin edition and the later French translation to make Descartes’ reasoning as lucid and engaging as possible. Also included in this edition is a brief introduction to Descartes and the _Meditations_, revised and expanded from Andrew Bailey’s acclaimed anthology, _First (...) Philosophy_. The introduction helps the reader to understand the context and purpose of Descartes’ project without over-explaining his arguments. (shrink)

This dissertation develops and defends a detailed realist, internalist account of qualia which is consistent with physicalism and which does not resurrect the epistemological 'myth of the Given.' In doing so it stakes out a position in the sparsely populated middle ground between the two major opposing factions on the problem of phenomenal consciousness: between those who think we have a priori reasons to believe that qualia are irreducible to the physical , and those who implicitly or explicitly treat qualia (...) as contentful but non-phenomenal physical properties . ;I present a minimal, non-question-begging definition of "qualia" and then use this definition in a reformulation of the argument from perceiver relativity which shows that qualia must, at least in humans, be properties of states of the central nervous system. That is, brain states do not simply indicate the colours of external objects---they instantiate phenomenal colours. Since brain states are not coloured in the same way as are external objects, I argue that to token phenomenal property F must be to be the first-person phenomenal sensation of F. I build on this position to argue that the phenomenal apprehension of qualia, is "given"---immediate, certain and private---but that qualia nevertheless do not provide an absolutely certain epistemological foundation since they do not constitute a set of indisputable propositions about facts. I then define what it would be for physicalism to be true of qualia, but argue that the main a priori arguments for and against qualia physicalism---including the logical possibility of zombies and the impossibility of epiphenomenalism---fail. Whether qualia are consistent with physicalism, I claim, is still an open question, answerable only when we discover in more detail how qualia depend upon the brain. ;Although strongly in sympathy with many commonsensical intuitions about qualia, this account stands in contrast to most influential extant theories of qualia, such as eliminativism , externalism , or property-dualism : I conclude the dissertation by using its results to argue explicitly against these three positions. (shrink)

The first part of this paper defends a 'two-factor' approach to mental representation by moving through various choice-points that map out the main peaks in the landscape of philosophical debate about representation. The choice-points considered are: (1) whether representations are conceptual or non-conceptual; (2) given that mental representation is conceptual, whether conscious perceptual representations are analog or digital; (3) given that the content of a representation is the concept it expresses, whether that content is individuated extensionally or intensionally; (4) whether (...) intensional contents are individuated by external or internal conditions; and (5) given that conceptual content is determined externally, whether the possession conditions for concepts are external or internal. The final part of the paper examines the relationship between representation and consciousness, arguing that any account of mental representation, though necessary for a complete account of consciousness, cannot be sufficient for it. (shrink)

Working memory--the ability to keep important information in mind while comprehending, thinking, and acting--varies considerably from person to person and changes dramatically during each person's life. Understanding such individual and developmental differences is crucial because working memory is a major contributor to general intellectual functioning. This volume offers a state-of-the-art, integrative, and comprehensive approach to understanding variation in working memory by presenting explicit, detailed comparisons of the leading theories. It incorporates views from the different research groups that operate on each (...) side of the Atlantic, and covers working-memory research on a wide variety of populations, including healthy adults, children with and without learning difficulties, older adults, and adults and children with neurological disorders. A particular strength of this volume is that each research group explicitly addresses the same set of theoretical questions, from the perspective of both their own theoretical and experimental work and from the perspective of relevant alternative approaches. Through these questions, each research group considers their overarching theory of working memory, specifies the critical sources of working memory variation according to their theory, reflects on the compatibility of their approach with other approaches, and assesses their contribution to general working memory theory. This shared focus across chapters unifies the volume and highlights the similarities and differences among the various theories. Each chapter includes both a summary of research positions and a detailed discussion of each position. Variation in Working Memory achieves coherence across its chapters, while presenting the entire range of current theoretical and experimental approaches to variation in working memory. (shrink)